https://opendata.uni-halle.de//handle/1981185920/35794 Tue, 17 Mar 2026 08:31:35 GMT 2026-03-17T08:31:35Z https://opendata.uni-halle.de//handle/1981185920/124620 Title: El 20-N de 1975 como un “tiempo del ahora” Author(s): Hofmann, Anna Catharina; Sesma, Nicolás; Mayayo i Artal, Andreu; Tébar Hurtado, Javier Abstract: Som encara a la reverberació que projecten els cinquanta anys del 20 de novembre de 1975, quan va morir el dictador Francisco Franco Bahamonde. Per referir-se a la càrrega que contenen les dates simbòliques, Walter Benjamin sostenia al seu manuscrit Tesi sobre la filosofia de la història publicat el 1942, després de la seva tràgica mort, que constitueixen un “temps de l'ara”. Concebut així, no es tractaria tant d'un mer registre cronològic sinó d'aquell instant que es pot reviure i ens permet accedir a una nova manera de comprendre la història. Un moment de connexió entre passat i present. Per aquest motiu, i també per altres raons, volem agrair de manera especial tant Anna Catharina Hofmann com Nico Sesma, tots dos amb obres que per diferents raons han constituït de manera recent aportacions rellevants per a la historiografia especialitzada a la dictadura del general Franco, que hagin acceptat la nostra invitació per participar en aquesta conversa. Sobretot per la seva ràpida i generosa resposta a col·laborar en un espai com és aquesta peculiar secció de Debats i diàlegs, una conversa oberta i directa, que ha acabat, amb el pas del temps, constituint-se en un tret definitori de Segle XX. Revista catalana d’història des de la seva creació el 2008. Wed, 01 Jan 2025 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/124620 2025-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/124603 Title: MIM-diode-like rectification in lateral 1T/1H/1T-MoS2 homojunctions via interfacial dipole engineering Author(s): Eckmann, Elias; Şas̜ıoğlu, Ersoy; Hinsche, Nicki F.; Mertig, Ingrid Abstract: Lateral 2D tunnel diodes that reproduce metal-insulator-metal (MIM)-diode-like rectification without using dissimilar contacts are attractive for scalable nanoelectronics. MoS2 can exist in both the semiconducting 1H phase and the metallic 1T phase, enabling phase-engineered homojunctions within a single material. First-principles electronic structure and quantum transport calculations show that phase-engineered 1T/1H/1T–MoS2 homojunctions exhibit pronounced MIM-diode-like rectification originating from interfacial charge transfer at asymmetric 1T/1H interfaces. The charge transfer establishes interface dipole steps that impose a built-in potential drop across the 1H barrier, thereby generating a trapezoidal tunnel barrier at zero bias. In contrast, symmetric 1T/1H interfaces do not form an interface dipoles and show no rectification. To clarify the microscopic origin, a lateral graphene/hexagonal-boron-nitride/graphene junction is analyzed as a minimal MIM diode analogue with a simple interface and well-defined barrier, confirming that interface-induced dipoles, rather than work-function difference, enable the effect. The mechanism operates entirely within a single monolayer material system and does not rely on out-of-plane stacking, highlighting compatibility with phase patterning in 2D semiconductors. These results establish lateral 1T/1H/1TMoS2 as a fully 2D, single-material platform for MIM-diode-like rectification and identify the interface-dipole engineering as a general strategy for designing ultrathin lateral tunnel diodes that can serve as building blocks for high-frequency detectors and energy-harvesting devices. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/124603 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/124602 Title: 25-Hydroxyvitamin D3 metabolism modulates the effect of variable UV exposure on 25-hydroxyvitamin D3 plasma concentrations Author(s): Scholze, Alexandra; Shinkov, Alexander; Slavov, Georgi S.; Luman, Merike; Vallianou, Natalia; Petrauskiene, Vaida; Stubnova, Viera; Wilson, Thomas; Hirche, Frank; Stangl, Gabriele I. Abstract: Background 25-hydroxyvitamin D3 (25(OH)D3) affects immune function, bone health, and reproduction. The precursor of 25(OH)D3, vitamin D3, is synthesized upon ultraviolet (UV) radiation exposure, the levels of which vary. Methods In a one-year observational study, we used multiple statistical approaches to examine 25(OH)D3 metabolism and UV exposure in 217 healthy men (aged 30–50 years) not using vitamin D supplementation, living between Athens and the Arctic Circle. Complementary data were obtained from six consecutive crews of Antarctic expeditioners. Results We show that, while vitamin D3 synthesis tracks UV exposure, resulting 25(OH)D3 concentrations are strongly shaped by the kinetics of 25(OH)D3 synthesis and degradation. Notably, the efficiency of 25(OH)D3 synthesis is high at low vitamin D3, but decreases markedly at higher vitamin D3. This results in comparable summer 25(OH)D3 maxima across European sites. Additionally, the kinetics of 25(OH)D3 degradation induces rapid seasonal concentration shifts, yet also exerts a moderating effect by dampening both seasonal maximum and minimum 25(OH)D3. Comparison of the seasonal patterns of plasma parameters and environmental parameters at European sites shows that vitamin D3 follows the UV exposure pattern, while 25(OH)D3 concentrations align with local temperature patterns. Antarctic data support the alignment between 25(OH)D concentrations and temperature. Conclusions The kinetics of 25(OH)D3 synthesis and degradation modulate the effect of variable UV exposure on 25(OH)D3 concentrations. This results in a regulated plasma signal reflecting local seasonal parameters. While absolute 25(OH)D3 concentrations are commonly investigated, future studies should also examine their temporal dynamics as a biological signal. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/124602 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/124601 Title: Phage therapy in revision arthroplasty : state of the art and application protocols Author(s): Wolfgart, Julius Michael; Schenker, Hanno; Gatz, Matthias; Migliorini, Filippo; Eschweiler, Jörg; Langwald, Steffen; Horz, Hans-Peter; Eisert, Albrecht; Schwanz, Thomas; Hofmann, Ulf Abstract: Introduction Periprosthetic joint infections (PJI) pose significant clinical challenges due to biofilm formation and antibiotic resistance. Standard treatment often involves implant removal and prolonged antibiotic therapy. Novel strategies target intracellular pathogens and biofilm-associated bacteria, including liposomal antibiotics, antimicrobial peptides, and bacteriophage therapy. Bacteriophages offer specificity and minimal disruption to human microbiota but remain experimental in PJI. Combining phages with targeted antibiotics shows promising results in preclinical models, though further research is needed to confirm efficacy in human PJI and optimise delivery methods. Objectives This study updates the current evidence on the use of bacteriophages for patients with PJI, proposing guidelines for their clinical application. Method PubMed was searched for articles containing phage therapy in revision arthroplasty. No additional filters or time constraints were used. All eligible studies were accessed by hand. Results A total of 39 studies (20 clinical, 19 reviews) on phage therapy for PJI were analysed, covering 56 patients. Of those, negative outcomes were only reported in five. Most studies involved elderly patients with periprosthetic infections of the knee or hip and showed high success rates when combined with antibiotics and surgery. Phage therapy was well tolerated, with only mild adverse effects, such as fever and reversible transaminitis, occurring predominantly with intravenous administration. Review articles reveal that despite promising outcomes, challenges remain, including a lack of standardisation, limited clinical data, and regulatory hurdles. Conclusion This study highlights the potential of phage therapy for PJI, emphasising its high specificity, ability to target antibiotic-resistant bacteria, and capacity to disrupt biofilms, and provides a guideline for its clinical administration. Clinical adoption, however, remains limited by regulatory barriers, lack of standardised protocols, and insufficient trial data. Key steps for implementation include establishing regulatory frameworks, developing academic–industrial partnerships and reference centres, and identifying indications supported by controlled trials. With these in place, phage therapy could become a promising adjunct in managing periprosthetic joint infections. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/124601 2026-01-01T00:00:00Z